Number 1 - 50/50
When I wrote about The Descendents, I mentioned that it nicely walked the line between funny and dramatic. 50/50 does it even better.
Joseph Gordon-Levitt came close to making the top of my list before with 500 Days of Summer - it hit number 2. The two movies can sit next to each other in a DVD collection whether grouped by name or by level of awesomeness. I don't think this movie works without him. James McAvoy was originally cast as Adam, and I can't imagine it.
My biggest surprise is how much I enjoyed Seth Rogan as Kyle. He dialed back his performance and took the backseat, yet he never disappears. While 50/50 looks at Adam's relationship with his girlfriend (Bryce Dallas Howard), it's Adam and Kyle who grow closer together in a natural way as a result of Adam's cancer. Considering that was the genesis of the script, and the role he played in real life, it works.
50/50 comes out at home later this month. I think it deserves a MUCH wider audience that it received. It came out at a bad time, and it's probably difficult to market a funny cancer movie. See it.I'm looking forward to seeing it again.